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Journal Articles

  1. Adams WK, D’souza AM, Sussman JL, Kaur S, Kieffer TJ, Winstanley CA. (2018). Enhanced amphetamine-induced motor impulsivity and mild attentional impairment in the leptin-deficient rat model of obesity. Physiol Behav, in press.
  2. Saber N, Bruin JE, O’Dwyer S, Schuster H, Rezania A, Kieffer TJ. (2018). Sex differences in maturation of human embryonic stem cell-derived β cells in mice. Endocrinology. 159(4):1827-1841.
  3. Neumann UH, Ho JSS, Chen S, Tam YYC, Cullis PR, Kieffer TJ. (2017). Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes. Molecular Metabolism. 6(10): 1161-1172.
  4. Ramzy A, Mojibian M, Kieffer TJ. (2017). Insulin deficient mouse β-cells do not fully mature but can be remedied through insulin replacement by islet transplantation. Endocrinology. 159(1):83-102.
  5. Kieffer TJ. (2017). In Memoriam-John C. Brown, PhD, DSc, FRSC, 1938-2016: Discoverer of GIP and motilin. Gastroenterology. 153(5):1169-1171.
  6. Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N. (2017). Beta cell replacement strategies for diabetes. Journal of Diabetes Investigation. 9(3):457-463.
  7. D’Souza AM, Neumann UH, Glavas MM, Kieffer TJ. (2017). The glucoregulatory actions of leptin. Molecular Metabolism. 6(9): 1052-1065.
  8. Ellis C, Ramzy A, Kieffer TJ. (2017). Regenerative medicine and cell-based approaches to restore pancreatic function. Nature Reviews. Gastroenterology & Hepatology. 14(10): 612-628.
  9. Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L. (2017). Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets. Molecular Metabolism. 6(8): 833-844.
  10. D’souza AM, Kieffer TJ. (2017). Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia. Molecular Metabolism. 6(6): 585-593.
  11. Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL. (2017). Insulin and glucagon: partners for life. Endocrinology. 158(4): 696-701.
  12. Shimazu-Kuwahara S, Harada N, Yamane S, Joo E, Sankoda A, Kieffer TJ, Inagaki N. (2017). Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice. Molecular Metabolism. 6(3): 288-294.
  13. Erener S, Marwaha A, Tan R, Panagiotopoulos C, Kieffer TJ. (2017). Profiling of circulating microRNAs in children with recent onset of type 1 diabetes. JCI Insight. 2(4): e89656.
  14. Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Sakagami H, Kitsunai H, Takiyama Y, Abiko A, Makino Y, Kieffer TJ, Haneda M. (2016) Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects. Molecular Metabolism. 6(2): 226-231.
  15. Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L. (2017). Dual Role of IL‐1β in Islet Amyloid Formation and its β‐Cell Toxicity: Implications in Type 2 Diabetes and Islet Transplantation. Diabetes, Obesity and Metabolism. 19(5): 682-694.
  16. Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussen B, Rodrigues B. (2017). Heparanase overexpression induces glucagon resistance and protects animals from chemically-induced diabetes. Diabetes. 66(1):45-57.
  17. D'souza AM, Johnson JD, Clee SM, Kieffer TJ. (2016). Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lep ob/ob mice. Molecular Metabolism. 5(11): 1103-12.
  18. Neumann UH, Ho JSS, Mojibian M, Covey SD, Charron MJ, Kieffer TJ. (2016). Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival. Molecular Metabolism. 5(8): 731-6.
  19. Denroche HC, Kwon MM, Glavas MM, Tuduri E, Philippe M, Quong WL, Kieffer TJ. (2016). The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy. Molecular Metabolism. 5(8): 716-724.
  20. Kieffer TJ. (2016). Closing in on mass production of human beta cells. Cell Stem Cell. 18(6): 699-702.
  21. Mojibian M, Glavas MM, Kieffer TJ. (2016). Engineering the gut for insulin replacement to treat diabetes. Journal of Diabetes Investigation. 7 Suppl 1: 87-93.
  22. Denroche HC, Glavas MM, Tudurí E, Karunakaran S, Quong WL, Philippe M, Britton HM, Clee SM, Kieffer TJ. (2016). Disrupted leptin signaling in the lateral hypothalamus and ventral premammillary nucleus alters insulin and glucagon secretion and protects against diet-induced obesity. Endocrinology. 157(7): 2671-85.
  23. Wills QF, Boothe T, Asadi A, Ao Z, Warnock GL, Kieffer TJ, Johnson JD. (2016). Statistical approaches and software for clustering islet cell functional heterogeneity. Islets. 8(2): 48-56.
  24. Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, Tan R, Kieffer TJ, Verchere CB, Panagiotopoulos C, Levings MK. (2016). T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. The Journal of Clinical Investigation. 126(3): 1039-51.
  25. Bruin JE, Saber N, O'Dwyer S, Fox JK, Mojibian M, Arora P, Rezania A, Kieffer TJ. (2016). Hypothyroidism impairs human stem cell-derived pancreatic progenitor cell maturation in mice. Diabetes. 65(5): 1297-309.
  26. Quiskamp N, Bruin JE, Kieffer TJ. (2015). Differentiation of human pluripotent stem cells into β-cells: Potential and challenges. Best Practice & Research. Clinical Endocrinology & Metabolism. 29(6): 833-47.
  27. Neumann UH, Denroche HC, Mojibian M, Covey SD, Kieffer TJ. (2016). Insulin knockout mice have extended survival but volatile blood glucose levels on leptin therapy. Endocrinology. 157(3): 1007-12.
  28. Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Atageldiyeva KK, Takiyama Y, Abiko A, Makino Y, Kieffer TJ, Haneda M. (2016). Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice. Diabetologia. 59(3): 533-41.
  29. Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JT, Xu EE, Taghizadeh F, O'Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD. (2016). Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation. Cell Metabolism. 23(1): 179-93.
  30. Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez MF. (2016). Glucose-dependent insulinotropic polypeptide stimulates osteopontin expression in the vasculature via endothelin-1 and CREB. Diabetes. 65(1): 239-54.
  31. Konorov SO, Schulze HG, Gage BK, Kieffer TJ, Piret JM, Blades MW, Turner RF. (2015). Process analytical utility of raman microspectroscopy in the directed differentiation of human pancreatic insulin positive cells. Analytical Chemistry. 87(21): 10762-9.
  32. Adams WK, Sussman JL, Kaur S, D'souza AM, Kieffer TJ, Winstanley CA. (2015). Long-term, calorie restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling two markers of addiction vulnerability. The European Journal of Neuroscience. 42(12): 3095-104.
  33. Bruin JE, Rezania A, Kieffer TJ. (2015). Replacing and safeguarding pancreatic β cells for diabetes. Science Translational Medicine. 7(316): 316ps23.
  34. Gage BK, Asadi A, Baker RK, Webber TD, Wang R, Itoh M, Hayashi M, Miyata R, Akashi T, Kieffer TJ. (2015). The role of ARX in human pancreatic endocrine specification. PloS One. 10(12): e0144100.
  35. Bruin JE, Saber N, Braun N, Fox JK, Mojibian M, Asadi A, Drohan C, O'Dwyer S, Balzer D, Rezania A, Kieffer TJ. (2015). Treating diet-induced diabetes and obesity with macroencapsulated human embryonic stem cell-derived progenitor cells and antidiabetic drugs. Stem Cell Reports. 4(4): 605-620.
  36. Kwon MM, O'Dwyer SM, Baker RK, Covey SD, Kieffer TJ. (2015). FGF21-mediated improvements in glucose clearance require uncoupling protein 1. Cell Reports. 13(8): 1521-7.
  37. Asadi A, Bruin JE, Kieffer TJ. (2015). Characterization of antibodies to products of proinsulin processing using immunofluorescence staining of pancreas in multiple species. The Journal of Histochemistry and Cytochemistry. 63(8): 646-62.
  38. Bruin JE, Asadi A, Fox JK, Erener S, Rezania A, Kieffer TJ. (2015). Accelerated maturation of human stem cell-derived pancreatic progenitor cells into insulin-secreting cells in immunodeficient rats relative to mice. Stem Cell Reports. 5(6): 1081-96.
  39. Denroche HC, Kwon MM, Quong WL, Neumann UH, Kulpa JE, Karunakaran S, Clee SM, Brownsey RW, Covey SD, Kieffer TJ. (2015). Leptin induces fasting hypoglycaemia in diabetic mice through the depletion of glycerol. Diabetologia. 58(5): 1100-8.
  40. Park YJ, Woo M, Kieffer TJ, Hakem R, Safikhan N, Yang F, Ao Z, Warnock GL, Marzban L. (2014). The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets. Diabetologia. 57(4): 765-75.
  41. Tudurí E, Denroche HC, Kara JA, Asadi A, Fox JK, Kieffer TJ. (2014). Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis. American J Physiology. Endocrinology and Metabolism. 306(7): E748-55.
  42. Mojibian M, Lam AW, Fujita Y, Asadi A, Grassl GA, Dickie P, Tan R, Cheung AT, Kieffer TJ. (2014). Insulin-producing intestinal K cells protect nonobese diabetic mice from autoimmune diabetes. Gastroenterology. 147(1): 162-171.
  43. Neumann UH, Chen S, Tam YY, Baker RK, Covey SD, Cullis PR, Kieffer TJ. (2014). IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. Endocrinology. 155(3): 716-25.
  44. Cho YM, Fujita Y, Kieffer TJ. (2014). Glucagon-like peptide-1: glucose homeostasis and beyond. Ann Rev Physiol. 76: 535-59.
  45. Bruin JE, Erener S, Vela J, Hu X, Johnson JD, Kurata HT, Lynn FC, Piret JM, Asadi A, Rezania A, Kieffer TJ. (2014). Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells. Stem Cell Research. 12(1): 194-208.
  46. Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Mojibian M, Albrecht T, Yang YHC, Johnson JD, Kieffer TJ. (2014). Reversal of diabetes with insulin producing cells derived in vitro from human pluripotent stem cells. Nature Biotechnology. 32(11): 1121-1133.
  47. D'souza AM, Asadi A, Johnson JD, Covey SD, Kieffer TJ. (2014). Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis. Endocrinology. 155(4): 1268-79.
  48. Gage BK, Baker RK, Kieffer TJ. (2014). Overexpression of PAX4 reduces glucagon expression in differentiating hESCs. Islets. 6(2): e29236.
  49. Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD. (2013). A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology. 57(2): 543-54.
  50. Denroche HC, Quong WL, Bruin JE, Tuduri E, Asadi A, Glavas MM, Fox JK, Kieffer TJ. (2013). Leptin administration enhances islet transplant performance in diabetic mice. Diabetes. 62(8): 2738-46.
  51. Tudurí E, Bruin JE, Denroche HC, Fox JK, Johnson JD, Kieffer TJ. (2013). Impaired Ca(2+) signaling in βcells lacking leptin receptors by Cre-loxP recombination. PloS One. 8(8): e71075.
  52. Cho YM, Wideman RD, Kieffer TJ. (2013). Clinical application of glucagon-like peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus. Endocrinology and Metabolism (Seoul). 28(4): 262-274.
  53. Rezania A, Bruin JE, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ. (2013). Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells. 31(11): 2432-42.
  54. Ahlqvist E, Osmark P, Kuulasmaa T, Pilgaard K, Omar B, Brøns C, Kotova O, Zetterqvist AV, Stancáková A, Jonsson A, Hansson O, Kuusisto J, Kieffer TJ, Tuomi T, Isomaa B, Madsbad S, Gome. (2013). Link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes. 62(6): 2088-94.
  55. Erener S, Mojibian M, Fox JK, Denroche HC, Kieffer TJ. (2013). Circulating miR-375 as a biomarker of βcell death and diabetes in mice. Endocrinology. 154(2): 603-8.
  56. Gage BK, Webber TD, Kieffer TJ. (2013). Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells. PloS One. 8(12): e82076.
  57. Park YJ, Ao Z, Kieffer TJ, Chen H, Safikhan N, Thompson DM, Meloche M, Warnock GL, Marzban L. (2013). The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation. Diabetologia. 56(3): 508-19.
  58. Daoust J, Chen M, Wang M, Williams DE, Garcia Chavez MA, Wang YA, Merchant CE, Fontana A, Kieffer TJ, Andersen RJ. (2013). Sesterterpenoids isolated from a northeastern Pacific Phorbas sp. Journal of Organic Chemistry. 78(17): 8267-73.
  59. Cummings BP, Bremer AA, Kieffer TJ, D'Alessio D, Havel PJ. (2013). Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques. Journal of Endocrinology. 216(2): 207-15.
  60. Mojibian M, Harder B, Hurlburt A, Bruin JE, Asadi A, Kieffer TJ. (2013). Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes. Diabetologia. 56(10): 2213-21.
  61. Caron NJ, Gage BK, O'Connor MD, Eaves CJ, Kieffer TJ, Piret JM. (2013). A human embryonic stem cell line adapted for high throughput screening. Biotechnology and Bioengineering. 110(10): 2706-16.
  62. Bruin JE, Rezania A, Xu J, Narayan K, Fox JK, O'Neil JJ, Kieffer TJ. (2013). Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice. Diabetologia. 56(9): 1987-98.
  63. Szabat M, Lynn FC, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. (2012). Maintenance of β-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes. 61(6): 1365-71.
  64. Bround MJ, Asghari P, Wambolt RB, Bohunek L, Smits C, Philit M, Kieffer TJ, Lakatta EG, Boheler KR, Moore ED, Allard MF, Johnson JD. (2012). Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice. Cardiovascular Research. 96(3): 372-80.
  65. Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ, Ao Z, Warnock GL, Kieffer TJ. (2012). Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes. 61(8): 2016-29.
  66. Park YJ, Lee S, Kieffer TJ, Warnock GL, Safikhan N, Speck M, Hao Z, Woo M, Marzban L. (2012). Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia. 55(4): 1035-1047.
  67. Yang GK, Fredholm BB, Kieffer TJ, Kwok YN. (2012). Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout mice. American Journal of Physiology. Endocrinology and Metabolism. 303(2): E180-90.
  68. Gaddy DF, Riedel MJ, Bertera S, Kieffer TJ, Robbins PD. (2012). dsAAV8-mediated gene transfer and βcell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice. Gene Therapy. 19(8): 791-9.
  69. Cho YM, Merchant CE, Kieffer TJ. (2012). Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacology & Therapeutics. 135(3): 247-78.
  70. Hoesli CA, Kiang RL, Mocinecová D, Speck M, Mošková DJ, Donald-Hague C, Lacík I, Kieffer TJ, Piret JM. (2012). Reversal of diabetes by βTC3 cells encapsulated in alginate beads generated by emulsion and internal gelation. Journal of Biomedical Materials Research. 100(4): 1017-28.
  71. Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M. (2012). Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. Diabetologia. 55(2): 404-12.
  72. Yang GK, Squires PE, Tian F, Kieffer TJ, Kwok YN, Dale N. (2012). Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets. Islets. 4(1): 64-70.
  73. Tudurí E, Bruin JE, Kieffer TJ. (2012). Restoring insulin production for type 1 diabetes. Journal of Diabetes. 4(4): 319-31.
  74. Levi J, Huynh FK, Denroche HC, Neumann UH, Glavas MM, Covey SD, Kieffer TJ. (2012). Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia. 55(3): 752-62.
  75. Angevine KR, Wuescher LM, Andrews K, Alexander LA, McInerney MF, Kieffer TJ, Mensah-Osman EJ. (2012). Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling in the proximal duodenum. Nutrition & Diabetes. 2: e55.
  76. Denroche HC, Huynh FK, Kieffer TJ. (2012). The role of leptin in glucose homeostasis. Journal of Diabetes Investigation. 3(2): 115-129.
  77. Mehran AE, Templeman NM, Brigidi GS, Lim GE, Chu KY, Hu X, Botezelli JD, Asadi A, Hoffman BG, Kieffer TJ, Bamji SX, Clee SM, Johnson JD. (2012). Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Cell Metabolism. 16(6): 723-37.
  78. Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ. (2012). Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia. 55(2): 372-81.
  79. Speck M, Cho YM, Asadi A, Rubino F, Kieffer TJ. (2011). Duodenal-jejunal bypass protects GK rats from beta-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. American Journal of Physiology. Endocrinology and Metabolism. 300(5): E923-32.
  80. Szabat M, Kalynyak TB, Lim GE, Chu KY, Yang YH, Asadi A, Gage BK, Ao Z, Warnock GL, Piret JM, Kieffer TJ, Johnson JD. (2011). Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes. Cell Death & Disease. 2: e232.
  81. Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, Wendt A, Jonsson A, De Marinis YZ, Berglund LM, Taneera J, Balhuizen A, Hansson O, Osmark P, Dunér P, Brøns C, Stancáková A, Kuusisto J, Bugliani M, Saxena R, Ahlqvist E, Kieffer TJ, Tuomi T, Isomaa B, Melander O, Sonestedt E, Orho-Melander M, Nilsson P, Bonetti S, Bonadonna R, Miccoli R, Delprato S, Marchetti P, Madsbad S, Poulsen P, Vaag A, Laakso M, Gomez MF, Groop L. (2011). Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes. 60(9): 2424-33.
  82. Yang GK, Yip L, Fredholm BB, Kieffer TJ, Kwok YN. (2011). Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach. Journal of Pharmacology and Experimental Therapeutics. 336(1): 77-86.
  83. Levi J, Gray SL, Speck M, Huynh FK, Babich SL, Gibson WT, Kieffer TJ. (2011). Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance. Endocrinology. 152(9): 3385-95.
  84. Tudurí E, Kieffer TJ. (2011). Reprogramming gut and pancreas endocrine cells to treat diabetes. Diabetes, Obesity & Metabolism. 13 Suppl 1: 53-9.
  85. Hoesli CA, Raghuram K, Kiang RL, Mocinecová D, Hu X, Johnson JD, Lacík I, Kieffer TJ, Piret JM. (2011). Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation. Biotechnology and Bioengineering. 108(2): 424-34.
  86. Denroche HC, Levi J, Wideman RD, Sequeira RM, Huynh FK, Covey SD, Kieffer TJ. (2011). Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes. 60(5): 1414-23.
  87. Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB. (2011). Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. Journal of Clinical Investigation. 121(8): 3024-8.
  88. Rezania A, Riedel MJ, Wideman RD, Karanu F, Ao Z, Warnock GL, Kieffer TJ. (2011). Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes. 60(1): 239-47.
  89. Cho YM, Kieffer TJ. (2011). New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser. Diabetologia. 54(2): 219-22.
  90. Fujita Y, Asadi A, Yang GK, Kwok YN, Kieffer TJ. (2010). Differential processing of pro-glucose dependent insulinotropic polypeptide in gut. American Journal of Physiology. Gastrointestinal and Liver Physiology. 298(5): G608-14.
  91. Riedel MJ, Kieffer TJ. (2010). Treatment of diabetes with glucagon-like peptide-1 gene therapy. Expert Opinion on Biological Therapy. 10(12): 1681-92.
  92. Hill JA, Szabat M, Hoesli CA, Gage BK, Yang YH, Williams DE, Riedel MJ, Luciani DS, Kalynyak TB, Tsai K, Ao Z, Andersen RJ, Warnock GL, Piret JM, Kieffer TJ, Johnson JD. (2010). A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression. PloS One. 5(9): e12958.
  93. Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD, Kieffer TJ. (2010). Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes. 59(12): 3032-40.
  94. Widenmaier SB, Kim SJ, Yang GK, De Los Reyes T, Nian C, Asadi A, Seino Y, Kieffer TJ, Kwok YN, McIntosh CH. (2010). A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control. PloS One. 5(3): e9590.
  95. Ngai YF, Quong WL, Glier MB, Glavas MM, Babich SL, Innis SM, Kieffer TJ, Gibson WT. (2010). Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis. Endocrinology. 151(11): 5226-36.
  96. Fujita Y, Wideman RD, Asadi A, Yang GK, Baker R, Webber T, Zhang T, Wang R, Ao Z, Warnock GL, Kwok YN, Kieffer TJ. (2010). Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology. 138(5): 1966-75.
  97. Law E, Lu S, Kieffer TJ, Warnock GL, Ao Z, Woo M, Marzban L. (2010). Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3. Diabetologia. 53(7): 1415-27.
  98. Riedel MJ, Gaddy DF, Asadi A, Robbins PD, Kieffer TJ. (2010). DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes. Gene Therapy. 17(2): 171-80.
  99. Gaddy DF, Riedel MJ, Pejawar-Gaddy S, Kieffer TJ, Robbins PD. (2010). In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/ db mouse model of diabetes. Diabetes. 59(12): 3108-16.
  100. Gage BK, Riedel MJ, Karanu F, Rezania A, Fujita Y, Webber TD, Baker RK, Wideman RD, Kieffer TJ. (2010). Cellular reprogramming of human amniotic fluid cells to express insulin. Differentiation. 80(2-3): 130-9.
  101. Gray SL, Donald C, Jetha A, Covey SD, Kieffer TJ. (2010). Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling. Endocrinology. 151(9): 4178-86.
  102. Daoust J, Fontana A, Merchant CE, de Voogd NJ, Patrick BO, Kieffer TJ, Andersen RJ. (2010). Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway. Organic Letters. 12(14): 3208-11.
  103. Yang GK, Chen JF, Kieffer TJ, Kwok YN. (2009). Regulation of somatostatin release by adenosine in the mouse stomach. Journal of Pharmacology and Experimental Therapeutics. 329(2): 729-37.
  104. Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ. (2009). Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. American Journal of Physiology - Endocrinology and Metabolism. 296(3): E473-9.
  105. Wideman RD, Gray SL, Covey SD, Webb GC, Kieffer TJ. (2009). Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Molecular Therapy. 17(1): 191-8.
  106. Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine JP. (2009). Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatric Research. 65(1): 39-44.
  107. Unniappan S, Wideman RD, Donald C, Gunn V, Wall JL, Zhang QX, Webber TD, Cheung AT, Kieffer TJ. (2009). Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells. Journal of Molecular Medicine. 87(7): 703-12.
  108. Riedel MJ, Lee CW, Kieffer TJ. (2009). Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice. American Journal of Physiology. Endocrinology and Metabolism. 296(4): E936-44.
  109. Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD, Kieffer TJ, Abrahani A, Rodrigues B. (2009). Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Diabetes. 58(11): 2464-75.
  110. Wideman RD, Kieffer TJ. (2009). Mining incretin hormone pathways for novel therapies. Trends in Endocrinology and Metabolism. 20(6): 280-6.
  111. Forestieri R, Merchant CE, de Voogd NJ, Matainaho T, Kieffer TJ, Andersen RJ. (2009). Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway. Organic Letters. 11(22): 5166-9.
  112. Unniappan S, Kieffer TJ. (2008). Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295(1): R51-8.
  113. Fujita Y, Chui JW, King DS, Zhang T, Seufert J, Pownall S, Cheung AT, Kieffer TJ. (2008). Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon expressing L cells. American Journal of Physiology. Endocrinology and Metabolism. 295(3): E648-57.
  114. Unniappan S, Speck M, Kieffer TJ. (2008). Metabolic effects of chronic obestatin infusion in rats. Peptides. 29(8): 1354-61.
  115. Khazaei M, Moien-Afshari F, Kieffer TJ, Laher I. (2008). Effect of exercise on augmented aortic vasoconstriction in the db/db mouse model of type-II diabetes. Physiological Research. 57(6): 847-56.
  116. Moien-Afshari F, Ghosh S, Elmi S, Raham MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey RW, Laher I. (2008). Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/ db mice. Diabetologia. 51(7): 1327-37.
  117. Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS, Kieffer TJ. (2008). Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin. Molecular Therapy. 16(6): 1138-45.
  118. Wideman RD, Fujita Y, Kieffer TJ. (2007). Insulin-expressing engineered cell lines and primary cells: surrogate beta-cells from liver, gut and other sources. Current Opinions in Organ Transplantation. 12(1): 67-72.
  119. Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ. (2007). A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes. 56(11): 2744-52.
  120. Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ. (2006). Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proceedings of the National Academy of Sciences of the United States of America. 103(36): 13468-73.
  121. Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ. (2006). The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metabolism. 4(4): 291-302.
  122. Unniappan S, McIntosh CH, Demuth HU, Heiser U, Wolf R, Kieffer TJ. (2006). Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY. Diabetologia. 49(8): 1915-23.
  123. Lam NT, Covey SD, Lewis JT, Oosman S, Webber T, Hsu EC, Cheung AT, Kieffer TJ. (2006). Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. Journal of Molecular Endocrinology. 36(1): 163-74.
  124. Stock S, Leichner P, Wong AC, Ghatei MA, Kieffer TJ, Bloom SR, Chanoine JP. (2005). Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. Journal of Clinical Endocrinology and Metabolism. 90(4): 2161-8.
  125. Nyberg J, Anderson MF, Meister B, Alborn AM, Ström AK, Brederlau A, Illerskog AC, Nilsson O, Kieffer TJ, Hietala MA, Ricksten A, Eriksson PS. (2005). Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation. Journal of Neuroscience. 25(7): 1816-25.
  126. Laubner K, Kieffer TJ, Lam NT, Niu X, Jakob F, Seufert J. (2005). Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cells. Diabetes. 54(12): 3410-7.
  127. Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ. (2004). Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. Journal of Clinical Endocrinology and Metabolism. 89(6): 2963-72.
  128. Wideman RD, Kieffer TJ. (2004). Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate. Hormone and Metabolic Research. 36(11-12): 782-6.
  129. Kieffer TJ. (2004). Gastro-intestinal hormones GIP and GLP-1. Annales of Endocrinology (Paris). 65(1): 13-21.
  130. Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI, Kieffer TJ. (2004). Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells. Journal of Molecular Endocrinology. 32(2): 415-24.
  131. Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G, van der Kooy D. (2004). Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nature Biotechnology. 22(9): 1115-24.
  132. Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS. (2004). Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express pancreatic and duodenal homeobox gene-1 age-dependently. Review of Diabetic Studies. 1(2): 66-79.
  133. Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ. (2004). Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Molecular Endocrinology. 18(6): 1333-45.
  134. Fujita Y, Cheung AT, Kieffer TJ. (2004). Harnessing the gut to treat diabetes. Pediatric Diabetes. 5 Suppl 2: 57-69.
  135. Kieffer TJ. (2003). GIP or not GIP? That is the question. Trends in Pharmacological Sciences. 24(3): 110-2.
  136. Wideman RD, Kieffer TJ. (2003). Developing strategies to increase circulating levels of glucagon-like peptide-1. Canadian Journal of Diabetes. 27: 120-1.
  137. Lam NT, Kieffer TJ. (2002). The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent. Minerva Endocrinologica. 27(2): 79-93.
  138. Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA. (2001). Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. 50(5): 1004-11.
  139. Daniel PB, Kieffer TJ, Leech CA, Habener JF. (2001). Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide type 1 receptor selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis. Journal of Biological Chemistry. 276(16): 12938-44.
  140. D'Alessio DA, Kieffer TJ, Taborsky GJ, Havel PJ. (2001). Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. Journal of Clinical Endocrinology and Metabolism. 86(3): 1253-9.
  141. Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM. (2000). Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 49(5): 741-8.
  142. Lewis JT, Dayanandan B, Habener JF, Kieffer TJ. (2000). Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology. 141(10): 3710-6.
  143. Kieffer TJ, Lam NT, Cheung AT. (2000). Insulin production from the β-cell: antagonistic roles of GLP-1 and leptin. Canadian Journal of Diabetes Care. 24: 47-57.
  144. Cheung AT, Dayanandan B, Lewis JT, Korbutt GS, Rajotte RV, Bryer-Ash M, Boylan MO, Wolfe MM, Kieffer TJ. (2000). Glucose-dependent insulin release from genetically engineered K cells. Science. 290(5498): 1959-62.
  145. Baggio L, Kieffer TJ, Drucker DJ. (2000). Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice. Endocrinology. 141(10): 3703-9.
  146. Kieffer TJ, Habener JF. (2000). The adipoinsular axis: effects of leptin on pancreatic beta-cells. American Journal of Physiology. Endocrinology and Metabolism. 278(1): E1-E14.
  147. Kieffer TJ, Habener JF. (1999). The glucagon-like peptides. Endocrine Reviews. 20(6): 876-913.
  148. Seufert J, Kieffer TJ, Habener JF. (1999). Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proceedings of the National Academy of Sciences of the United States of America. 96(2): 674-9.
  149. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF. (1999). Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. Journal of Clinical Endocrinology and Metabolism. 84(2): 670-6.
  150. Yip RG, Boylan MO, Kieffer TJ, Wolfe MM. (1998). Functional GIP receptors are present on adipocytes. Endocrinology. 139(9): 4004-7.
  151. Heller RS, Kieffer TJ, Habener JF. (1997). Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes. 46(5): 785-91.
  152. Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF. (1997). Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes. 46(6): 1087-93.
  153. Tseng CC, Kieffer TJ, Jarboe LA, Usdin TB, Wolfe MM. (1996). Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat. Journal of Clinical Investigation. 98(11): 2440-5.
  154. Kieffer TJ, Heller RS, Unson CG, Weir GC, Habener JF. (1996). Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets. Endocrinology. 137(11): 5119-25.
  155. Pederson RA, Kieffer TJ, Pauly R, Kofod H, Kwong J, McIntosh CH. (1996). The enteroinsular axis in dipeptidyl peptidase IV-negative rats. Metabolism. 45(11): 1335-41.
  156. Morrow GW, Kieffer TJ, McIntosh CH, MacGillivray RT, Brown JC, St Pierre S, Pederson RA. (1996). The insulinotropic region of gastric inhibitory polypeptide; fragment analysis suggests the bioactive site lies between residues 19 and 30. Canadian Journal of Physiology and Pharmacology. 74(1): 65-72.
  157. Kieffer TJ, Heller RS, Habener JF. (1996). Leptin receptors expressed on pancreatic beta-cells. Biochemical and Biophysical Research Communications. 224(2): 522-7.
  158. Schieldrop PJ, Gelling RW, Elliot R, Hewitt J, Kieffer TJ, McIntosh CH, Pederson RA. (1996). Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA. Biochimica et Biophysica Acta. 1308(2): 111-3.
  159. Heller RS, Kieffer TJ, Habener JF. (1996). Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochemical and Biophysical Research Communications. 223(3): 624-32.
  160. Kieffer TJ, McIntosh CH, Pederson RA. (1995). Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology. 136(8): 3585-96.
  161. Kieffer TJ, Huang Z, McIntosh CH, Buchan AM, Brown JC, Pederson RA. (1995). Gastric inhibitory polypeptide release from a tumor-derived cell line. American Journal of Physiology. 269(2 Pt 1): E316-22.
  162. Kieffer TJ, Schieldrop PJ, McLean E, Donaldson EM, Brown JC. (1994). A radioimmunoassay for oncorhynchid growth hormone targeted to the physiological range. Canadian Journal of Physiology and Pharmacology. 72(10): 1155-61.
  163. Mayer I, McLean E, Kieffer TJ, Souza LM, Donaldson EM. (1994). Antisomatostatin-induced growth acceleration in chinook salmon (Oncorhynchus tshawytscha). Fish Physiology and Biochemistry. 13(4): 295-300.
  164. Kieffer TJ, Buchan AM, Barker H, Brown JC, Pederson RA. (1994). Release of gastric inhibitory polypeptide from cultured canine endocrine cells. American Journal of Physiology. 267(4 Pt 1): E489-96.
  165. Kieffer TJ, Verchere CB, Fell CD, Huang Z, Brown JC, Pedersen RA. (1993). Glucose-dependent insulinotropic polypeptide stimulated insulin release from a tumor-derived beta-cell line (beta TC3). Canadian Journal of Physiology and Pharmacology. 71(12): 917-22.

Book Chapters

  1. Gage BK , Wideman RD , Kieffer TJ. (2013). Generating pancreatic endocrine cells from pluripotent stem cells. Islam S. Islets of Langerhans. (48): 1335-73. Springer-Verlag, Germany
  2. Bruin JE , Kieffer TJ. (2012). Differentiation of human embryonic stem cells into pancreatic endocrine cells. Hayat MA. Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury. (18): 191-206. Springer, Germany
  3. Cho YM , Kieffer TJ. (2010). K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Litwack G. Vitamins and Hormones, Vol 84: Incretins and Insulin Secretion. (84): 111-150. Academic Press, United Kingdom
  4. Cheung AT, Hsu EC, Calos M, Kieffer TJ. (2007). Gut reaction to stem cell therapy for diabetes. Herold E.Burrill Stem Cell Report: Progress and Prospects. 94-102. Burrill & Company
  5. Habener JF, Kieffer TJ. (2005). Glucagon and glucagon-like peptides. Kahn RC, Weir GC, King GL, Moses AC, Smith RJ, Jacobson AM. Joslin's Diabetes Mellitus. 14: 179-193. Lippincott Williams & Wilkins, Philadelphia, United States
  6. Wideman RD, Kieffer TJ. (2005). Metabolic actions of the glucagon-like peptides. Zempleni J, Dakshinamurti K. Nutrients and Cell Signaling. : 565-585. Marcel Dekker, Inc., New York, United States
  7. Cheung AT, Kieffer TJ. (2004). Gene therapy for metabolic disease. LeRoith D, Taylor SI, Olefsky M. Diabetes Mellitus: A Fundamental and Clinical Text. 3: 747-762. Lippincott Williams & Wilkins, Philadelphia, United States
  8. Kieffer TJ. (2003). Glucose-dependent insulinotropic polypeptide (GIP): Role in energy homeostasis. Greeley GH. Encyclopedia of Hormones & Related Cell Regulators. : 150-157. Academic Press, New York, United States
  9. Kieffer TJ, Hussain MA, Habener JF. (2001). Glucagon and glucagon-like peptide production and degradation. Jefferson LS, Cherrington AD. Handbook of Physiology, Section 7: The Endocrine System. : 197-265. Oxford University Press, New York, United States
  10. Wolfe MM, Boylan MO, Kieffer TJ, Tseng CC. (1999). Glucose-dependent insulinotropic polypeptide (GIP): Incretin vs. enterogastrone. Conn MP, Greeley GH. Gastrointestinal Endocrinology. : 439-446. Humana Press, Totowa, United States